Spice
Cayenne
7/10 Moderate evidence
Ground hot chili pepper containing capsaicin, which acts on TRPV1 receptors to reduce pain signaling over time.
Active compounds
-
Capsaicin
TRPV1 agonist; depletes substance P from sensory neurons, reducing nociceptive signaling
Helps with
Practical tips
- Preparation
- Sprinkle on soups, eggs, and roasted vegetables
- Recommended amount
- 1/4 to 1/2 teaspoon daily
- Absorption
- Topical capsaicin creams (0.025-0.075%) are effective for localized arthritis and neuropathy pain
- Cautions
- Can aggravate GERD, ulcers, and hemorrhoids; topical use can cause burning